I only caught the tail end of Wil Wheaton's speech. He was absolutely hysterical, and a perfect fit as the keynote speaker. Lucky for me the first PA panel followed directly after. Gabe and Tycho broke through the curtains on stage to "Everyday I'm Hustlin" entrance music, which redefined the word "awesome".
The panel was back and forth questions from audience members for an hour straight. Quite a few were filled with sexual euphemisms, or lead to Tycho trashing Gabe's gaming skills. Audience members even requested the pair to fill requests, the best of which having Tycho sing "My Belruel" on stage while attendees held their DS's and lighters up, concert style.

Closing the panel, Uwe Boll made his appearance on stage and also took a turn at fielding questions. He showed the trailer to his new movie Postal, which deals closely with the World Trade Center. Quite a few people in the audience got very angry. It was a drama fueled day over here at PAX!
There is a second PA panel coming up this weekend. We'll be there to check it out.